A finite state machine synthesizer

This thesis presents a Finite State Machine (FSM) Synthesizer developed at Portland State University. The synthesizer starts from a high level behavioral description, in which no states are specified, and generates the lower level FSM descriptions for simulation and physical layout generation

Association between baseline pulse pressure and hospital mortality in non-traumatic subarachnoid hemorrhage patients: a retrospective cohort study

Background and purposePrevious studies have described an association between pulse pressure (PP) level and mortality in stroke patients. Evidence of associations between PP level and the risk of mortality remains unknown in non-traumatic subarachnoid hemorrhage (SAH) patients. We aimed to explore the relationship between the baseline PP level and hospital mortality.MethodsThis cohort study of 693 non-traumatic SAH adults used Medical Information Mart for Intensive Care (MIMIC-IV) data from 2008–2019 admissions to Intensive Care Unit (ICU). PP level was calculated as the first value after admission to the ICU. The endpoint of the study was in-hospital mortality. Cox proportional hazards models were utilized to analyze the association between baseline PP level and hospital mortality. Restricted Cubic Splines (RCS) analysis was utilized to determine the relationship curve between hospital mortality and PP level and examine the threshold saturation effect. We further applied Kaplan–Meier survival curve analysis to examine the consistency of these correlations. The interaction test was used to identify subgroups with differences.ResultsThe mean age of the study population was 58.8 ± 14.6 years, and 304 (43.9%) of participants were female. When baseline PP level was assessed in quartiles, compared to the reference group (Q1 ≤ 56 mmHg), the adjusted hazard ratio (HR) in Q2 (57–68 mmHg), Q3(69–82 mmHg), Q4 (≥83 mmHg) were 0.55 (95% CI: 0.33–0.93, p = 0.026), 0.99 (95% CI, 0.62–1.59, p = 0.966), and 0.99 (95% CI: 0.62–1.59, p = 0.954), respectively. In the threshold analysis, for every 5 mmHg increase in PP level, there was an 18.2% decrease in hospital mortality (adjusted HR, 0.818; 95% CI, 0.738–0.907; p = 0.0001) in those with PP level less than 60 mmHg, and a 7.7% increase in hospital mortality (adjusted HR, 1.077; 95% CI, 1.018–1.139; p = 0.0096) in those with PP level was 60 mmHg or higher.ConclusionFor patients with non-traumatic SAH, the association between baseline PP and risk of hospital mortality was non-linear, with an inflection point at 60 mmHg and a minimal risk at 57 to 68 mmHg (Q2) of baseline PP level

Development of a New Surface Acoustic Wave Based Gyroscope on a X-112°Y LiTaO3 Substrate

A new micro gyroscope based on the surface acoustic wave (SAW) gyroscopic effect was developed. The SAW gyroscopic effect is investigated by applying the surface effective permittivity method in the regime of small ratios of the rotation velocity and the frequency of the SAW. The theoretical analysis indicates that the larger velocity shift was observed from the rotated X-112°Y LiTaO3 substrate. Then, two SAW delay lines with reverse direction and an operation frequency of 160 MHz are fabricated on a same X-112°Y LiTaO3 chip as the feedback of two SAW oscillators, which act as the sensor element. The single-phase unidirectional transducer (SPUDT) and combed transducers were used to structure the delay lines to improve the frequency stability of the oscillator. The rotation of a piezoelectric medium gives rise to a shift of the propagation velocity of SAW due to the Coriolis force, resulting in the frequency shift of the SAW device, and hence, the evaluation of the sensor performance. Meanwhile, the differential structure was performed to double the sensitivity and compensate for the temperature effects. Using a precise rate table, the performance of the fabricated SAW gyroscope was evaluated experimentally. A sensitivity of 1.332 Hz deg−1 s at angular rates of up to 1,000 deg s−1 and good linearity are observed

Advances in SAW Gas Sensors Based on the Condensate-Adsorption Effect

A surface-acoustic-wave (SAW) gas sensor with a low detection limit and fast response for volatile organic compounds (VOCs) based on the condensate-adsorption effect detection is developed. In this sensor a gas chromatography (GC) column acts as the separator element and a dual-resonator oscillator acts as the detector element. Regarding the surface effective permittivity method, the response mechanism analysis, which relates the condensate-adsorption effect, is performed, leading to the sensor performance prediction prior to fabrication. New designs of SAW resonators, which act as feedback of the oscillator, are devised in order to decrease the insertion loss and to achieve single-mode control, resulting in superior frequency stability of the oscillator. Based on the new phase modulation approach, excellent short-term frequency stability (±3 Hz/s) is achieved with the SAW oscillator by using the 500 MHz dual-port resonator as feedback element. In a sensor experiment investigating formaldehyde detection, the implemented SAW gas sensor exhibits an excellent threshold detection limit as low as 0.38 pg

A Novel Particulate Matter 2.5 Sensor Based on Surface Acoustic Wave Technology

Design, fabrication and experiments of a miniature particulate matter (PM) 2.5 sensor based on the surface acoustic wave (SAW) technology were proposed. The sensor contains a virtual impactor (VI) for particle separation, a thermophoretic precipitator (TP) for PM2.5 capture and a SAW sensor chip for PM2.5 mass detection. The separation performance of the VI was evaluated by using the finite element method (FEM) model and the PM2.5 deposition characteristic in the TP was obtained by analyzing the thermophoretic theory. Employing the coupling-of-modes (COM) model, a low loss and high-quality SAW resonator was designed. By virtue of the micro electro mechanical system (MEMS) technology and semiconductor technology, the SAW based PM2.5 sensor detecting probe was fabricated. Then, combining a dual-port SAW oscillator and an air sampler, the experimental platform was set up. Exposing the PM2.5 sensor to the polystyrene latex (PSL) particles in a chamber, the sensor performance was evaluated. The results show that by detecting the PSL particles with a certain diameter of 2 μm, the response of the SAW based PM2.5 sensor is linear, and in accordance with the response of the light scattering based PM2.5 monitor. The developed SAW based PM2.5 sensor has great potential for the application of airborne particle detection

An Aerosol Sensor for Multi-Sized Particles Detection Based on Surface Acoustic Wave Resonator and Cascade Impactor

This research proposed the design, fabrication, and experiments of a surface acoustic wave resonator (SAWR)-based multi-sized particles monitor. A wide range selection and monitoring of large coarse particles (LCP), inhalable particles (PM10), and fine inhalable particles (PM2.5) were achieved by combining high-performance 311 MHz SAWRs and a specially designed cascade impactor. This paper calculated the normalized sensitivity distribution of the chip to the mass loading effect, extracted the optimal response area for particle attachment, analyzed the influence of the distance between nozzle and chip surface on the particle distribution, and evaluated the collection efficiency of the specially designed 2 LPM (L/min) impactor through computational fluid dynamics simulation software. An experimental platform was built to conduct the response experiment of the sensor to particle-containing gas generated by the combustion of leaf fragments and repeatability test. We verified the results of the particle diameter captured at each stage. This research suggests that the sensor’s response had good linearity and repeatability, while the particles collected on the surface of the SAWR in each impactor stage met the desired diameter, observed through a microscope

Mass Sensitivity Optimization of a Surface Acoustic Wave Sensor Incorporating a Resonator Configuration

The effect of the sensitive area of the two-port resonator configuration on the mass sensitivity of a Rayleigh surface acoustic wave (R-SAW) sensor was investigated theoretically, and verified in experiments. A theoretical model utilizing a 3-dimensional finite element method (FEM) approach was established to extract the coupling-of-modes (COM) parameters in the absence and presence of mass loading covering the electrode structures. The COM model was used to simulate the frequency response of an R-SAW resonator by a P-matrix cascading technique. Cascading the P-matrixes of unloaded areas with mass loaded areas, the sensitivity for different sensitive areas was obtained by analyzing the frequency shift. The performance of the sensitivity analysis was confirmed by the measured responses from the silicon dioxide (SiO2) deposited on different sensitive areas of R-SAW resonators. It is shown that the mass sensitivity varies strongly for different sensitive areas, and the optimal sensitive area lies towards the center of the device

Regulation of endogenous acyl homoserine lactones by microbial density to enhance syntrophism of acetogens and methanogens in anaerobic digestion

To understand the syntrophic mechanism of acetogens and methanogens in anaerobic digestion (AD), functional floras of syntrophic propionate-oxidizing bacteria (SPOB), syntrophic butyrate-oxidizing bacteria (SBOB), aceticlastic methanogens (AM) and hydrogenotrophic methanogens (HM) were separately tested by microbial density to reveal their performance in metabolic activity, extracellular polymeric substances (EPS) production and quorum sensing (QS) signal molecules (acyl homoserine lactones, AHLs) secretion, as well as the regulation of endogenous AHLs in balancing the social behaviors of syntrophic microorganism. The results showed that methanogenesis, EPS production and AHLs secretion of the functional floras were all observably affected by microbial density. The metabolic activity of SBOB, SPOB, AM and HM decreased with a microbial density more than 344, 295, 229 and 237 mgMLVSS/L, respectively. The intraspecific regulation of SPOB and HM were achieved with the mediation of OXOC6-HSL and C10-HSL, respectively. With the mediation of enjoyed signal molecules, metabolic coordination between SPOB and AM was of bidirectional regulation, but it was a unidirectional regulation from HM to SPOB. Syntrophic acetogens and methanogens in AD could bidirectionally regulate their EPS production via QS system to construct syntrophic floras that make the methane fermentation of propionate and butyrate more efficient. The present research work provides a practical strategy to regulate endogenous AHLs by microbial density to enhance the syntrophism of acetogens and methanogens in AD

A Novel Particulate Matter 2.5 Sensor Based on Surface Acoustic Wave Technology

Design, fabrication and experiments of a miniature particulate matter (PM) 2.5 sensor based on the surface acoustic wave (SAW) technology were proposed. The sensor contains a virtual impactor (VI) for particle separation, a thermophoretic precipitator (TP) for PM2.5 capture and a SAW sensor chip for PM2.5 mass detection. The separation performance of the VI was evaluated by using the finite element method (FEM) model and the PM2.5 deposition characteristic in the TP was obtained by analyzing the thermophoretic theory. Employing the coupling-of-modes (COM) model, a low loss and high-quality SAW resonator was designed. By virtue of the micro electro mechanical system (MEMS) technology and semiconductor technology, the SAW based PM2.5 sensor detecting probe was fabricated. Then, combining a dual-port SAW oscillator and an air sampler, the experimental platform was set up. Exposing the PM2.5 sensor to the polystyrene latex (PSL) particles in a chamber, the sensor performance was evaluated. The results show that by detecting the PSL particles with a certain diameter of 2 μm, the response of the SAW based PM2.5 sensor is linear, and in accordance with the response of the light scattering based PM2.5 monitor. The developed SAW based PM2.5 sensor has great potential for the application of airborne particle detection